TriAsorB™

To learn more about protecting vulnerable and sensitive skin, explore our recent studies highlighting the effectiveness of TriAsorB™ in preserving the integrity of theskin barrier​

Proven effectiveness of TriAsorB™ in preserving the skin barrier ​

PRESERVATION OFSKINHYDRATION​

Two complementary studies evaluated the protective effect of TriAsorB™ on water homeostasis using ex vivo and in vitro models.​

Raman microspectroscopy performed on samples of isolated human stratum corneum exposed to a simulated solar spectrum revealed a significant decrease in water-binding capacity following irradiation. Prior application of a sunscreen containing TriAsorB™ improved these parameters by +30% and +15%, respectively, compared to the placebo (19).​

Metabolomic analyses also confirmed that the application of a sunscreen containing TriAsorB™ prevented alterations in natural moisturizing factors induced by solar radiation (8)

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MAINTAINING SKIN LIPID BALANCE​

In vitro and ex vivo evaluations have shown that sunscreen containing TriAsorB™ preserves skin surface lipids, as well as the underlying epidermal lipidome: 98% protection of skin lipids (20).​
- Ex vivo, it effectively reduces oxidative degradation, particularly that of squalene, linoleic acid, and cholesterol (19).​
- In vitro, lipidomic analysis demonstrated protection against photo-induced ceramide imbalance: up to 65% preservation of NS-type ceramides (CER[NS]), which are particularly involved in the pathophysiology of atopic dermatitis (8).​

More recent data have demonstrated TriAsorB™’s ability to stabilize the overall epidermal lipid profile: in the absence of sun protection, 252 lipids were dysregulated by sun exposure, compared to only 4 when the sunscreen was used (20).​

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PROTECTION OF THE SKIN MICROBIOME​

TriAsorB™ has also demonstrated its ability to preserve microbial diversity and prevent the proliferation of pro-inflammatory microorganisms in a skin ecosystem model.​
+82% protection of the skin’s defenses (11).​
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More specifically, commensal species such as Cutibacterium and Malassezia were preserved, as was the tryptophan metabolic pathway.​
Finally, the formation of 25-hydroxycholesterol—a biomarker of radiation-induced keratinocyte stress—was also completely prevented (11).​

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TriAsorB™, a new very broad-spectrum filter​

Phenylenebis-diphenyltriazine (TriAsorB™) is an innovative sunscreen filter that protects the skin against UVB, UVA, and high-energy visible (HEV) blue light.​

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TriAsorB™ and Genoprotection​

Formulation of an SPF 50+ very broad-spectrum sunscreen containing phenylene bis-diphenyltriazine (TriAsorB™), an innovative sunscreen ingredient with unique optical properties.​

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TriAsorB™ and Skin Pigmentation​

In vitro photoprotection and clinical evaluation of skin pigmentation induced by HEV blue light.​

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TriAsorB™ and protection of DNA repair mechanisms​

In vitro evaluation of protection against the impact of HEV blue light on DNA repair mechanisms​.

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TriAsorB™ Safety​

Mass spectrometry imaging and absorption methods visualizing the spatial distribution and penetration of the sunscreen into the skin.

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In vivo evaluation of TriAsorB™ efficacy​

In vivo method for evaluating photoprotection against HEV blue light.​

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Legal Notices 

3/ Bacqueville D, Jacques-Jamin C, Dromigny H, et al. Phenylene Bis-Diphenyltriazine (TriAsorB), a new sunfilter protecting the skin against both UVB and UVA radiation as well as blue light. Photochem Photobiol Sci. 2021;20(11):1475-1486. doi:10.1007/s43630-021-00114-x​

8/ Jacques C, Jamin EL, Noustens A, et al. Multi-omics analysis to evaluate the effects of solar exposure and a broad-spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model. Photochem Photobiol. 2025;101(2):373–385. doi:10.1111/php.14001​

11/ Jacques C, Bacqueville D, Jamin EL, et al. A multi-omics approach to understand the impact of sun exposure on an in vitro skin ecosystem and evaluate a new broad-spectrum sunscreen. Photochem Photobiol. 2024;100(2):477-490. doi:10.1111/php.13841​

19/ Assi A, Michael-Jubeli R, Duplan H, Baillet-Guffroy A, Tfayli A, Jacques-Jamin C. Effects of solar radiation on stratum corneum hydration: Part II, protective action of sunscreens. J Biophotonics. 2024;17(8):e202400107. doi:10.1002/jbio.202400107​

20/ Jacques C, Feucherolles M, Le W, et al. Impact of solar irradiation on lipidome dynamics and disruption using an in vitro 3D reconstructed epidermis model and a combination of advanced analytical methods. Int J Cosmet Sci. Published online June 6, 2025. doi:10.1111/ics.13077

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