Publication Summary

AVENE

Penetration Study of Formulated Nanosized Titanium Dioxide in Models of Damaged and Sun‐Irradiated Skins

Corinne Miquel‐Jeanjean, Frédéric Crépel, Véronique Raufast, Bruno Payre, Lucien Datas, Sandrine Bessou‐Touya, Hélène Duplan
Photochemistry and Photobiology
2012

This in vitro study shows that titanium dioxide, a sunscreen used in the white range, does not penetrate the skin.
To be effective and safe, sun filters are supposed to stay on the surface of the skin, whether it is healthy, damaged or exposed to radiation.
The product was applied (4 mg / cm²) for 24 hours on healthy skin explants, altered by removal of strips, and altered and irradiated.
The titanium dioxide was then quantified at the surface of the skin, in the stratum corneum, in the epidermis, the dermis, and beyond the explant.
It has been observed that titanium dioxide is found overwhelmingly on the surface of the skin and then in the stratum corneum.
Titanium dioxide therefore does not penetrate the skin and remains on the surface whether the skin is healthy, damaged or subjected to irradiation.