Summary of clinical results

AVENE
Concentré rougeur

Efficacy of ROSAMED Chronic redness concentrate - Comparative study on half-face (treated vs untreated)

Efficacy of ROSAMED Chronic redness concentrate in adults with mild to moderate erythrotelangiectatic rosacea, under dermatological control
Comparative half-face study (treated versus untreated)

Population

31 women aged 19 to 65 with mild to moderate erythematotelangiectatic rosacea

Application of ROSAMED Chronic redness concentrate

2 applications per day on half the face for 4 weeks

Application of usual moisturizer on the other half of the face

Evaluation criteria

  • Auto-assessment of flushing severity (GFSS Score = Global Flushing Severity Score) 
  • Auto-evaluation of erythema severity (Score from 1 = absent to 5 = extreme)
  • Perceived efficacy on rosacea symptoms
  • Instrumental measurement of erythema intensity (multispectral imaging)

Results

Intra-group analysis: Highly significant decrease in flush intensity at D29 for treated hemiface (p<0.001): 

  • 50% of subjects with moderate to extreme flushing improved
  • + 38.7% of subjects with no or mild flushing

Inter-group analysis: Significant improvement versus untreated hemifacial at D15 and D29 (p<0.05)

Image 1

Evolution of flushing intensity (GFSS score) after 4 weeks for treated hemi-face

 

  • Intra-group analysis: Highly significant decrease in erythema intensity at D29 (p<0.001): 
  • 53% of subjects with moderate to extreme erythema improved
  • + 51% of subjects with no or mild erythema
  • Inter-group analysis: Significant improvement versus untreated hemiface at D15 (p<0.05) and highly significant at D29 (p<0.001)
Image 2

Evolution of erythema intensity after 4 weeks for the treated hemi-face

 

  • Improvement of rosacea symptoms on the treated side perceived by 58% of subjects as early as D15 and by 67% of subjects at D29

  • Significant reduction in erythema on treated side at D29
Image 3

Evolution of erythema intensity (multispectral imaging) after 4 weeks

Conclusion

ROSAMED Chronic redness concentrate applied twice daily has demonstrated its efficacy on the intensity of flushing and erythema as early as 1 month