Summary of clinical results

AVENE
Cicalfate - Gel cicatrice

Tolerance and efficacy of CICALFATE+ scar gel as monotherapy

Tolerance and efficacy of CICALFATE+ scar gel as monotherapy in adolescents and adults with post-act residual marks, under dermatological and ophthalmological control

Population

54 subjects aged 12 to 64 with post-act residual marks on the face or body:

  • Post-sutures (n=10)
  • Post-caesarians (n=9)
  • Post-surgery / face (n=10)
  • Post-surgery / body (n=18)
  • Post-surgery / scalp (n=7)

Application of CICALFATE+ scar gel

  • 2 applications per day on residual marks (face or body) for 3 months

Evaluation criteria

  • Clinical scoring of scar appearance (POSAS score, Patient and Observer Scar Assessment Scale)
  • Rating of associated redness (spectrocolorimetry) 
  • Auto-evaluation of discomfort sensations (score from 0 to 10)
  • Skin and eye tolerance

Results

  • Highly significant improvement in scar appearance from D22 perceived by investigators: POSAS score -27% (p<0.001, versus T0)
Image 1

Changes in investigator-rated POSAS score over 3 months

** p= highly significant (p<0,001, versus T0)

 

  • Highly significant reduction in associated redness from first application: -5% (p<0.001, versus T0)
Image 2

Evolution of associated redness intensity (spectrocolorimetric measurements) over 3 months

** p= highly significant (p<0,001, versus T0)

 

  • Sensations of discomfort significantly alleviated by D22: -38% (p<0.001, versus T0)
Image 3

Changes in intensity of discomfort sensations over 3 months

** p= highly significant (p<0,001, versus T0)

 

  • Very good skin and ocular tolerance

Conclusion

CICALFATE+ scar gel applied twice daily:

  • improves the appearance of scars from 3 weeks
  • decreases associated redness from the first application. application

Very good skin and eye tolerance