Summary of clinical results
Dexeryl emollient cream, an effective treatment for skin dryness caused by kidney failure
Objective
To evaluate the efficacy of DEXERYL glycerin-paraffin emollient cream on uremic xerosis.
Methodology
Randomized, double-blind, intra-individual (left versus right comparison), multicenter clinical study comparing a glycerin/paraffin cream versus placebo in uremic xerosis.
Population
99 randomized patients with moderate to severe uremic xerosis.
Dosage
2 applications daily.
Duration
8 weeks.
Primary endpoint
Treatment response (xerosis score) on each leg, as defined by a reduction of at least two grades in five points from baseline in the clinical score on day 7.
Secondary endpoints
Patient self-assessment of overall pruritus (visual analog scale: VAS) and quality of life (SF-12 and DLQI scales).
Patient-assessed local tolerance and cosmetic acceptability.
Overall tolerance assessed by investigators
Tolerance
Dexeryl emollient cream is well accepted.
Conclusion
73% of patients significantly improved the dryness associated with their renal failure.
Regular application of Dexeryl emollient cream twice a day on the body enabled 73% of patients to see their xerosis greatly improved or absent, after 7 days¹. There is a 75% reduction in itching after 2 months of treatment1. 84% of patients are satisfied to very satisfied.
Publication
1- Balaskas et al. Randomized, Double-blind Study with Glycerol and Paraffin in Uremic Xerosis. Clin J Am Soc Nephrol. 2011
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