Publication Summary
Additional pharmacological activity of I-modulia and generation of two newly designed extracts of Aquaphilus dolomiae culture for dermocosmetic actives
Aquaphilus dolomiae (AD) is a rare bacteria isolated from Avène Thermal Spring Water. I-Modulia, the first biotech AD extract-G1 (ADE-G1), showed immuno modulating effects in Th2 inflammatory models.
New data demonstrate the favourable effects of ADE-G1 on inhibition of human mast cell degranulation in vitro and its effect on substance P-induced neurogenic inflammation on ex vivo human skin explants, that support its efficacy in inflammatory skin conditions.
In addition to ADE-G1, two de novo AD extracts (ADE-G2 and ADE-G3) were selected for their repairing and neuroinflammation modulation activities
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