Publication Summary
Cutaneous sensitivity modulation by Aquaphilus dolomiae extract-G3 on in vitro models of neuro-inflammation
Inflammatory skin disorders, including atopic dermatitis (AD), associated pruritus and sensitive skin, have a complex multifactorial pathogenesis including neurogenic inflammation involving the release in blood and skin of neurotransmitters such as substance P (SP).
In vitro models demonstrated the effect of the original biological extract of Aquaphilus dolomiae extract-G3 (ADE-G3) on cutaneous neurogenic inflammation, focusing on the role of SP as an inflammatory mediator in cutaneous neurogenic inflammation.
Topically applied, ADE-G3, once formulated, may improve neuro-inflammation in patients with inflammatory skin disorders.
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