Publication Summary

AVENE

Enhancing Facial Rejuvenation Outcomes With a Novel Retinaldehyde-Based Cream: A Comparative Randomized Intra-Individual Study

Camille Monteil, Valeria Barreto-Campos, Edward Lain, Emma Guillou, Gautier Doat, Thérèse Nocera
Journal of Cosmetic Dermatology
December 2025

Summary  

This randomized split-face study evaluated the Hyaluron Activ Procedure Lifting Cream, containing retinaldehyde, niacinamide, and hyaluronic acid in 66 subjects after chemical peels, HA injections, or fractional CO₂ laser. The product was applied once daily for 3 months starting after re-epidermization. 

The results prove not only clinical efficacy on all signs of aging over time, but also superiority compared to the area treated with the neutral cream: it is clinically proven that Hyaluron Activ Procedure lifting cream improves the results of aesthetic procedures.