Objective

To evaluate the efficacy of DEXERYL emollient cream in the treatment of people with senile xerosis.

Study

Single-center clinical study, comparing intra-individually the evolution of affected skin characteristics under topical administration of a glycerol- and paraffin-based emollient with 2 applications per day to affected areas.

Population

50 patients included, over 60 years of age, in good physical and psychological health, with no family history of severe skin disorders.

Dosage

2 applications daily.

Duration

28 days.

Primary endpoint

Assessment of the degree of xerosis based on the severity of 5 clinical parameters: desquamation, tightness, cracking, excoriation and erythema (4-level severity scale).

Secondary endpoints

Self-assessment of itching, measurement of Insensible Water Loss and stratum corneum water content.

Tolerance

A good tolerance profile and no episodes of undesirable side effects were observed.

Conclusion

98% of patients had no or mild signs of skin dryness after 1 month¹. 87% reduction in itching after 1 month¹. After 14 days, the skin was significantly hydrated¹.

Publication

_{1- Cristaudo A. et al. Efficacy of an emollient dermoprotective cream in the treatment of elderly skin affected by xerosis. G. Ital Dermatol Venerol, 2015}