Publication Summary
DUCRAY
Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®
Journal of the European Academy of Dermatology and Venereology
2018
Objective
Compare Cutibacterium acnes (C.acnes) colonization of the skin of acne patients with that of healthy subjects.
Evaluate the efficacy of a topical formulation containing Myrtacine® on the overall population of C.acnes and antibiotic-resistant strains in acne patients
Methodology
Bicentric study in 2 phases:
- Phase 1: Comparison of C. acnes microflora between acne-prone and healthy subjects
- Phase 2: Effect of KERACNYL PP + applied twice a day for 2 months in 60 subjects with mild to moderate acne
Evaluation Criteria
- Quantification of total and antibiotic-resistant C. acnes (culture)
- C. acnes subtyping: (MALDI-TOF)
- Quantification of porphyrins (virulence factor) (image analysis)
- Counting of non-inflammatory and inflammatory acne lesions (ECLA score, GEA score)
Results
- C. acnes type IA phylotype is dominant in acne sufferers
- After 2 months of application of a product containing Myrtacine®, - 25% fewer porphyrins, virulence factors of C. acnes
Reducing the population of antibiotic-resistant C. acnes
Conclusion
A topical formula containing Myrtacine® acts on the virulence of C. acnes and reduces the population of antibiotic-resistant C. acnes
Our other publications on this subject
Want to read on?
This access is reserved for professionals, registered on Pierre Fabre For Med.
To access the full content, please register or log in if you already have an account.