Objective

Evaluate the activity of Myrtacine® (patented Myrtus communis extract), used alone or in combination with antibiotics, on C. acnes biofilm

Methodology

Static and dynamic in vitro models of bacterial culture promoting biofilm formation

Evaluation Criteria

• Action of different concentrations of Myrtacine® on C. acnes biofilm formed over 48h
• Action of different concentrations of Myrtacine® on the formation of biofilm of 
• Action of Myrtacine® alone and in combination with erythromycin on C. acnes biofilms resistant to erythromycin and clindamycin

Results

• Myrtacine® has a dose-dependent antibacterial action on biofilm-forming C. acnes, on both antibiotic-sensitive and antibiotic-resistant strains.
• Myrtacine® limits C. acnes biofilm formation in a dose-dependent manner
• Myrtacine® and erythromycin act in synergy on the biofilm of erythromycin-resistant C. acnes strains

 Conclusion

• Preventive and curative action of Myrtacine® on C. acnes biofilm
• Synergistic action of Myrtacine® and erythromycin on the biofilm of resistant C. acnes strains