Summary of clinical results

DUCRAY
Melascreen Concentré

Tolerance and efficacy of MELASCREEN Anti-Spots Concentrate

Tolerance and efficacy of MELASCREEN Anti-Spots Concentrate in subjects with superficial facial hyperpigmentation (lentigo, melasma, post-inflammatory hyperpigmentation related to acne), under dermatological and ophthalmological control

Population

  • 55 adult women (22 to 63 years old) with superficial facial hyperpigmentation (lentigo [n=14], melasma [n=32], post-inflammatory hyperpigmentation related to acne [n=9])
  • Phototypes II to V; All skin types

 

Application of MELASCREEN Anti-spots concentrate

  • Application twice a day to the entire face, neck and décolleté for 8 weeks
  • Photoprotection recommended in case of sun exposure

 

Evaluation criteria

  • Clinical scoring of overall efficacy on hyperpigmentation by the investigators (score from 0 = ineffective to 3 = very effective) 
  • Spectrometric evaluation of pigmentation (ITA angle measurement) of a pre-selected hyperpigmented area compared to an adjacent non-hyperpigmented control area
  • Perceived efficacy and cosmetic acceptability evaluated by the subjects (score from 0 to 10; percentage of satisfaction)
  • Skin and eye tolerance

Results

  • Efficacy perceived by the investigators on the reduction of hyperpigmentation for 85.5% of subjects at D57
Melascreen • Tolérance et efficacité-1
  • Significant evolution (p=0.005) of the difference in angle ITA° between hyperpigmentation and the control area (= depigmenting and unifying effect) of hyperpigmentation from 2 weeks
Melascreen • Tolérance et efficacité
  • Efficacy perceived by the subjects: evenness of the complexion for 94% of the subjects at 1 month (average score of 8/10)
  • Light, non-sticky texture for 100% of subjects (average score of 9.4 and 8.6 respectively) at 2 months
  • Good skin tolerance and excellent eye tolerance

Conclusion

  • Depigmenting efficacy and uniformity of the complexion
  • Very good cosmetic acceptability
  • Good tolerance

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