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A Well-Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16-Week Controlled Study

Virginie Turlier, Mélanie Froliger, Virginie Ribet, Valérie Mengeaud, Pascal Reygagne
Journal of Cosmetic Dermatology
23rd December 2024

Aims 

To assess the dermatological tolerance and clinical efficacy of a hair serum containing three plant-derived active ingredients (a Silybum marianum extract, Manganese PCA, and a Lespedeza capitata extract) in women with chronic telogen effluvium. 

 

Methodology 

  • 16-week, open-label, two-arm, controlled, parallel-group study of 64 women aged 46 ± 10 years with chronic telogen effluvium and a positive hair pull test
  • One treated group (study serum and neutral shampoo) and one control group (neutral shampoo only) 

 

Assessment criteria: 

  • Serum tolerance assessment
  • Hair pull test
  • 60’s hair count
  • Clinical rating/self-assessment
  • Quality of life questionnaire 

Results:  

  • Good dermatological tolerance of the serum as good at week (W) 16.
  • Significant reductions in the amount of hair lost during hair pull tests at week 8 and week 16 in the treated group
Graphique Publication sérum NEOPTIDE
*p < 0.05, †p = 0.0542 (W12). W, week.
  • Total number of hairs shed in 60 s significantly lower at W4, W8, and W12 in the treated group
Publication NEOPTIDE graph 2
*p < 0.05.W, week.
  • Decrease in hair loss over the study period reported by more subjects in the treated group. 
Publication NEOPTIDE graph 3
Between‐group differences: p < 0.01 at all‐time points. W, week.
  • Significant improvement in hair volume, density, strength, and thickness in the treated group. 
Publication NEOPTIDE graph 4
*p < 0.05. W, week.
  • Subjects were less depressed, less annoyed and less embarrassed by their hair loss at the end of the study in the treated group. 

Conclusion:  

The serum was well-tolerated and had a significant anti-hair loss effect in women with chronic telogen effluvium. This effect positively impacted quality of life. 

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