Summary of clinical results
Effects of Helichrysum Gymnocephalum in Pruritus associated to Atopic dermatitis
Pharmacological efficacy of Helichrysum Gymnocephalum in pruritogenic pathway in atopic dermatitis
Anti-inflammatory effect of Helichrysum gymnocephalum on IL-8 and TSLP
Culture of keratinocytes (N= 3)
Creation of an inflammation simulation with keratinocytes stimulated by IL-4 and IL-13 for 24h
Anti-inflammatory effect of Helichrysum gymnocephalum on JAK 1/2-STAT6 pathway
JAK inhibitors are considered as the main treatments in Atopic Dermatitis.
It was, therefore, important for us to carry out a pharmacological study in the JAK pathway to compare the efficacy of our active ingredient to JAK inhibitors.
IL-4/IL-3 Stimulation : 15min
STAT6 phosphorylation
Important communication link between IL-31 and Brain Natriuretic Peptide (BNP)
IL-31 plays a major role in pruritus by causing the multiplication and development of neuritis (neurosensory fibers) via biomarkers such as BNP. Augmented release and synthesis by IL-31 of BNP might contribute to central and peripheral itch signaling.
Anti-inflammatory effect of Helichrysum gymnocephalum on Brain Natriuretic Peptide (BNP)
Co-culture of sensory neurons and keratinocytes.
Anti-inflammatory effect of Helichrysum gymnocephalum on nerve growth
Co-culture of sensory neurons and keratinocytes.
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Conclusion
Helichrysum gymnocephalum extract inhibits :
- The production of TSLP and IL-8
- The phosphorylation of JAK/STAT pathway
Helichrysum gymnocephalum has demonstrated its effectiveness in blocking neurite outgrowth as well as the production of BNP.
There is, thus, a specific anti-inflammatory and antipruritogenic properties for Atopic Dermatitis through JAK/STAT pathway.
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