Summary of clinical results

DUCRAY
Dexyane Crème barrière isolante

Tolerance and efficacy of DEXYANE insulating barrier cream

Tolerance and efficacy of DEXYANE insulating barrier cream on pediatric and adult populations with chronic hand eczema and exposed to irritants, under dermatological control

Population

43 patients with atopic or contact (allergic or irritant) chronic hand eczema (CHE), divided into 2 groups: 

32 adults

  • CHE (30% atopy / 7% allergy / 63% irritation) 
  • IGA score: score 1 (n=2) score 2 (n=12) score 3 (n=18) 

11 children 

  • Atopic CHE 
  • Hands exposed to irritants

 

Application of DEXYANE insulating bareer cream

Application 3 times a day for adults, 2 to 3 times for children, for 3 weeks

 

Evaluation criteria

  • Evaluation of the evolution of physical and functional signs (scores from 0 to 4)
  • Illustrative photographs
  • Scoring of the insulating effect by the investigators
  • Skin tolerance under dermatological control
  • Cosmetic acceptability

Results

  • From 8 days, significant improvement in physical and functional signs
  • Effective to very effective insulating effect for 90% of patients after 3 weeks according to the investigators
  • Very good skin tolerance on all targets
  • Very good cosmetic acceptability
     

Evolution of clinical signs after 3 weeks of application of the barrier cream (assessed using a 5-point scale (0 = absent, 1 = very mild, 2 = mild, 3 = moderate, 4 = severe); illustrative photographs.

Jour 1

Day 1

Jour 8

Day 8

Jour 22

Day 22

Conclusion

  • Insulating and protective effect against household or occupational irritants
  • Very good skin tolerance

More summaries of clinical results