Summary of clinical results

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Efficacy and safety of CLEANANCE COMEDOMED+ Intensive anti-blemish care - International observational study

Efficacy and tolerability of CLEANANCE COMEDOMED+ Intensive anti-blemish care prescribed alone, in combination with anti-acne medication or as a relay treatment, in adolescents and adults with mild to moderate acne
International observational study

Population

4230 subjects from 21 different countries, aged 12 to 25, with mild to moderate facial acne (GEA score 1 to 3):

  • 50.6% mixed acne (retentional and inflammatory)

  • 36.2% retentional acne

  • 13.2% inflammatory acne

Application of CLEANANCE COMEDOMED+ Intensive anti-blemish care

2 applications per day on the face for 2 to 3 months 

  • 46.9% as monotherapy
  • 48.3% in combination with medication (zinc gluconate, BPO, azelaic acid, erythromycin, topical isotretinoin, glycolic acid, clindamycin, adapalene, salicylic acid, minocycline, spironolactone)
  • 4.8% as relay treatment

 

Evaluation criteria

  • Severity of acne (GEA score = Global Evaluation of Acne)
  • Efficacy perceived by investigators
  • Quality of life questionnaire (CADI scale 0 to 15)
  • Skin tolerance

Results

  • Highly significant improvement in acne severity score at follow-up visit (2-3 months): -36.4% (p<0.001, versus Inclusion)
COMEDOMED+ - Mean GEA score

Change in acne severity score (GEA) after 2 to 3 months

** p= Statistically Highly Significant (p<0.001, versus Inclusion)

 

  • Anti-imperfection effect perceived by investigators in over 80% of subjects in each population subgroup at follow-up visit (2-3 months)
COMEDOMED+ - Efficacy overall assessment

Anti-acne efficacy perceived by investigators in each subgroup after 2 to 3 months

 

  • Highly significant improvement in quality of life score at follow-up visit (2-3 months): -44.2% (p<0.001, versus Inclusion)
COMEDOMED+ - Quality of life

Evolution of quality of life score after 2 to 3 months

** p= Statistically Highly Significant (p<0.001, versus Inclusion)

 

  • Skin tolerance good to very good for 94.7% of subjects

Conclusion

CLEANANCE COMEDOMED+ Soin intensif anti-imperfections applied twice-daily has demonstrated its anti-acne efficacy and benefits in terms of quality of life in a large international cohort.

Good to very good cutaneous tolerance

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