Objective

To demonstrate the benefits of using Dexeryl emollient cream in the treatment of mild-to-moderate atopic dermatitis in children, by assessing Dexeryl's ability to prevent flare-ups and reduce the use of corticosteroids.

Study

International, multicenter, randomized, parallel, open-label.

Population

335 children aged 2 to 6 with mild-to-moderate atopic dermatitis, recruited during a flare-up and treated with a strong topical corticosteroid, and randomized once lesions had cleared (111 treated with Dexeryl, 116 treated with the reference emollient and 108 without emollient treatment).

Dosage

Dexeryl twice a day on the whole body, reference emollient three times a day on affected body areas.

Duration

12 weeks (intermediate assessments after 4 and 8 weeks).

Primary endpoint

Percentage of patients with at least one flare-up after12 weeks.

Secondary endpoints

Time to first flares, time to complete remission, number of flare-ups, percentage of patients requiring corticosteroids or immunosuppressants at weeks 4, 8 and 12, corticosteroid consumption.

Tolerance

Good tolerance was observed.

Conclusion

With regular, prolonged application during remission period, DEXERYL Emollient Cream spares eczema flares ups¹.

Publications

_{1 - Tiplica G.S. et al. The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomised controlled study. JEADV 2018}

_{2- Tiplica G.S. et al. Prevention of flares in children with atopic dermatitis with regular use of an emollient containing glycerol and paraffin: a randomized controlled study. Pediatric Dermatology 2017}