CLEANANCE
COMEDOMED +
Intensive anti-blemish care
CLEANANCE COMEDOMED+ is an intensive anti-imperfection skincare product that acts early on the pathophysiology of acne by targeting the comedo-switch, the tipping point in the differentiation of sebaceous stem cells. Thanks to 25% Comedoclastin™*, a patented active ingredient derived from milk thistle, it modulates the expression of the K75 protein, a key marker of the comedo-switch, and inhibits the formation of the microcomedo, the initial lesion of acne.
Enriched with 4% Niacinamide, the formula boosts anti-marking and anti-inflammatory action, while improving skin quality. It also offers continuous hydration for 24 hours**, with a peak of +82%** from the very first hour, ensuring comfort and tolerance even on sensitive skin.
This new skin care product combats acne lesions right from the root, with 1-year*** anti-recurrence activity. Can be used as a first-line treatment, in combination with medication or as a relay.
- Legal information
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* Patent pending
**Instrumental test on 33 subjects.
*** Limits reappearance of blemishes. Clinical scoring, 2 applications per day for 12 months, 51 subjects.
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For whom?From 9 years oldAdultsBreastfeedingPregnant woman
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Price30mL
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Texture- Creamy gel texture- Non-greasy finish
Patient relations
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Application tips
Apply morning and evening to skin cleansed with a CLEANANCE hygiene product.
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In combination with the following treatments
Comedomed+ Intensive Care can be used on its own or in combination with an anti-acne medication.
Mechanism of action of Comedoclastin™
Ingredients
Active ingredients:
A key plant of European phytotherapy formerly known for its numerous culinary or therapeutic uses, Avène Dermatological Laboratories are the first to select Milk Thistle for its powerful and patented activities to red
Acts on persistent marks, improves the appearance of pores and moisturizes.
Formula details:
Click on an ingredient type to highlight it in the list
Clinical results and publications
Efficacy results
1 year2
inflammatory lesions, open comedones and scar marks (PIE and PIH)3
continuous hydration4
Tolerance results
Good skin tolerance and excellent ocular tolerance1
Terms of use
1Tolerability and efficacy on target under ctrl, DTO and OPH
2Limitsreappearance of imperfections. Clinical scoring, 2 applications per day for 12 months, 51 subjects.
3Clinicalscoring, 39 subjects with 2 applications per day for 2 months. Results after 14 days of use
4Instrumental teston 33 subjects.
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